Cellular and molecular features of neurogenic skeletal muscle atrophy
نویسندگان
چکیده
منابع مشابه
Molecular and cellular mechanisms of skeletal muscle atrophy: an update
Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term immobilization, malnutrition, severe burns, aging as well as various serious and often chronic diseases, such as chronic heart failure, obstructive lung disease, renal failure, AIDS, sepsis, immune disorders, cancer,...
متن کاملCellular and molecular mechanisms of muscle atrophy
Skeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell and protein turnover. During muscle atrophy, proteolytic systems are activated, and contractile proteins and organelles are removed, resulting in the shrinkage of muscle fibers. Excessive loss of muscle mass is associated with poor prognosis in several diseases, including myopathies and muscular dystrophi...
متن کاملMolecular mechanisms of skeletal muscle atrophy
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date
متن کاملThe molecular basis of skeletal muscle atrophy.
Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional consequences. While the initiating physiological event leading to atrophy seems to be the loss of muscle tension and a good deal of the physiology of muscle atrophy has been characterized, little is known about the triggers or the molecular signaling events underlying this process. Decreases in protei...
متن کاملReversible molecular pathology of skeletal muscle in spinal muscular atrophy.
Low levels of full-length survival motor neuron (SMN) protein cause the motor neuron disease, spinal muscular atrophy (SMA). Although motor neurons undoubtedly contribute directly to SMA pathogenesis, the role of muscle is less clear. We demonstrate significant disruption to the molecular composition of skeletal muscle in pre-symptomatic severe SMA mice, in the absence of any detectable degener...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2020
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2020.113379